Table 2

Top GO CAN-processes ranked by the BN model or the HG enrichment test based on cancer genes from systematic sequencing of colorectal and breast cancer genomes

GO CAN-processes prioritized by the BN model

GO CAN-processes prioritized by the HG enrichment test

GO CAN-process

Total gene number

Cancer gene number

GO CAN-process

Total gene number

Cancer gene number

GO:0007016 cytoskeletal anchoring

10

3

GO:0007155 cell adhesion

689

34

GO:0030198 extracellular matrix organization and biogenesis

27

6

GO:0022610 biological adhesion

689

34

GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway

6

2

GO:0016043 cellular component organization and biogenesis

2,325

66

GO:0007155 cell adhesion

689

34

GO:0030198 extracellular matrix organization and biogenesis

27

6

GO:0007605 sensory perception of sound

116

9

GO:0048856 anatomical structure development

1,537

47

GO:0051318 G1 phase

18

2

GO:0007275 multicellular organismal development

1,797

52

GO:0006869 lipid transport

100

6

GO:0048731 system development

1,196

38

GO:0009112 nucleobase metabolic process

16

2

GO:0007519 striated muscle development

62

7

GO:0045661 regulation of myoblast differentiation

6

2

GO:0007605 sensory perception of sound

116

9

GO:0042593 glucose homeostasis

11

2

GO:0050954 sensory perception of mechanical stimulus

116

9

GO:0043534 blood vessel endothelial cell migration

6

2

GO:0016337 cell-cell adhesion

239

13

GO:0007183 SMAD protein complex assembly

4

2

GO:0032501 multicellular organismal process

3,128

73

GO:0060070 Wnt receptor signaling pathway through beta-catenin

5

2

GO:0007167 enzyme linked receptor protein signaling pathway

245

13

Median number

11

2

Median number

689

34

Wang et al. Genome Biology 2008 9:R174   doi:10.1186/gb-2008-9-12-r174