Method
Core promoters are predicted by their distinct physicochemical properties in the genome of Plasmodium falciparum
1 Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate - Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy
2 Department of Parasitology, Institute of Medical Science, The University of Tokyo 4-6-1, Shirokanedai, Minatoku, Tokyo 108-8639, Japan
Genome Biology 2008, 9:R178 doi:10.1186/gb-2008-9-12-r178
Published: 18 December 2008Abstract
Little is known about the structure and distinguishing features of core promoters in Plasmodium falciparum. In this work, we describe the first method to computationally identify core promoters in this AT-rich genome. This prediction algorithm uses solely DNA physicochemical properties as descriptors. Our results add to a growing body of evidence that a physicochemical code for eukaryotic genomes plays a crucial role in core promoter recognition.
