MAPP score distributions and comparison with experimental TSS distributions. A MAPP profile was generated for the region from 3,500 nucleotides upstream to 1,200 nucleotides downstream of every gene start codon in the P. falciparum genome (v2.1.4). These MAPP profiles were aligned at the 0 position (ATG codon) and the MAPP score averaged at each position. We smoothed the average MAPP score using a sliding window of 200 nucleotides and a shift of 100 nucleotides (blue circles). The TSSs distribution was generated from the frequency of FULL-Malaria TSSs at each distance from the closest ATG codon (red squares). Multiple TSSs that mapped to the same nucleotide were considered as a single mapping.
Brick et al. Genome Biology 2008 9:R178 doi:10.1186/gb-2008-9-12-r178