Genome Biology

official impact factor 6.89

Open Access Method

Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo

Zhandong Liu1,2, Min Wang1, James V Alvarez1, Megan E Bonney1, Chien-chung Chen1, Celina D'Cruz1, Tien-chi Pan1, Mahlet G Tadesse3 and Lewis A Chodosh1,2*

Author Affiliations

1 Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd, BRB II/III 616, Philadelphia, PA 19104, USA

2 Genomics and Computational Biology Graduate Group, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA

3 Department of Mathematics, Georgetown University, 2115 G Street NW, Washington, DC 20057, USA

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Genome Biology 2008, 9:R180 doi:10.1186/gb-2008-9-12-r180

Published: 18 December 2008

Additional files

Additional data file 1:

Gene signature for TGFβ pathway, including probe set ID, log fold change, gene name, Entrez ID, and gene symbol.

Format: XLS Size: 85KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional data file 2:

Gene signature for Ras pathway, including probe set ID, log fold change, gene name, Entrez ID, and gene symbol.

Format: XLS Size: 85KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional data file 3:

Genes in common between TGFβ signature and Ras signature.

Format: XLS Size: 19KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data