Figure 3.

An in vivo-derived Ras signature accurately and quantitatively predicts Ras pathway activation. (a) PCA demonstrating separation of mammary gland samples with Ras activation (MTB/TRAS 48 h, 96 h, 8 days and 14 days, filled triangles) from uninduced controls (MTB and MTB/TRAS 0 hours, open triangles) across principal component 1 (PC1). MTB/TRAS mice uninduced (open triangles) or induced (filled triangles) for 48 or 96 h were used for training, while the remaining MTB/TRAS time points and MTB uninduced mice were used as the test set. (b) SVD regression demonstrating quantitative prediction of Ras pathway activation following short-term induction in the mammary gland.