Figure 6.

A TGFβ signature detects TGFβ pathway activation in Ras-induced mammary tumors. (a) SVD regression predicts TGFβ pathway activation in mammary glands expressing activated Ras for 96 h and in mammary tumors induced by chronic Ras activation. (b) Western analysis showing increased phosphorylation of Smad1/3 in Ras-induced mammary tumors.