Table 2 |
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|
Genotype ratios of offspring at weaning following heterozygous intercrosses |
|||
| Observed |
Expected if semidominant, homozygous viable |
Expected if semidominant, homozygous lethal |
|
|
|
|||
| MommeD7 |
|||
| Heterozygote* |
65 |
60 |
|
| Wild type |
25 |
30 |
|
| MommeD8 |
|||
| Homozygote* |
14 |
27.5 |
|
| Heterozygote* |
56 |
55 |
|
| Wild type |
40 |
27.5 |
|
| MommeD9 |
|||
| Heterozygote* |
31 |
37.3 |
|
| Wild type |
25 |
18.7 |
|
| MommeD10 |
|||
| Homozygote* † |
14 |
77.25 |
|
| Heterozygote* † |
187 |
154.5 |
|
| Wild type |
108 |
77.25 |
|
|
|
|||
|
Offspring were classified as wild type, heterozygous or homozygous based on their GFP expression profiles. p-values: MommeD7, not significant; MommeD8, p < 0.005; MommeD9, not significant; MommeD10, p < 0.0001. *Progeny testing of mice classified based on GFP expression was carried out in a number of cases: 5 for MommeD7-/+, 11 for MommeD8-/-, 16 for MommeD8-/+, 8 for MommeD9-/+, 6 for MommeD10-/- and 11 for MommeD10-/+. In all cases the genotype was as expected. †Presumed genotype was confirmed by genotyping for 8 MommeD10-/- and 79 MommeD10-/+ mice. |
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|
Ashe et al. Genome Biology 2008 9:R182 doi:10.1186/gb-2008-9-12-r182 |
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