Intron mis-splicing: no alternative?
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Corresponding authors: Scott W Roy scottwroy@gmail.com - Manuel Irimia mirimia@gmail.com
1 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA
2 Departament de Genètica, Universitat de Barcelona, Barcelona 08028, Spain
Genome Biology 2008, 9:208 doi:10.1186/gb-2008-9-2-208
Published: 19 February 2008Abstract
A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.