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Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle

Chava Yanay^* , Noa Morpurgo^* and Michal Linial

Department of Biological Chemistry, Institute of Life Sciences, Givat Ram Campus, Hebrew University of Jerusalem, Jerusalem 91904, Israel

author email corresponding author email* Contributed equally

Genome Biology 2008, 9:R27doi:10.1186/gb-2008-9-2-r27


Published:	7 February 2008

Subject areas: Evolution, Genome studies, Neurobiology

Additional files

Additional data file 1:

Provided is a summary that lists the proteomes from multiple insect species and their evolutionary relatedness. A list of insect genome centers is compiled from NCBI Genome resources [114].

Format: EPS Size: 401KB Download file

Additional data file 2:

Part a provides a detailed table of the PS120 gene set and associated related information on gene names, synonyms, major partner proteins, and conservation levels from human to insect homologs. Part b is a complementary table based on the UniProtKB database [104].

Format: DOC Size: 507KB Download file

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Additional data file 3:

Listed are the 44 genes that had no clear homologs in certain insects. After homology search in the nucleotide databases, the majority could be accounted for as missed annotated genes.

Format: DOC Size: 92KB Download file

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Additional data file 4:

Provided is a ClustalW-based MSA of stoned B and SCAMP.

Format: EPS Size: 2.6MB Download file

Additional data file 5:

Provided is a ClustalW-based MSA of the SNARE syntaxin 1 and synapsin.

Format: EPS Size: 2.8MB Download file

Additional data file 6:

Provided are representative graphs of interactions for six proteins based on the STRING tool [110].

Format: EPS Size: 685KB Download file

Additional data file 7:

Provided is a detailed table of the PS120 gene set with the level of sequence identity and similarity (expressed as percentage between human and insects) and the protein valence according to the STRING tool.

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Additional data file 8:

Presented is a detailed table of gene functions in endocytosis and exocytosis (24 genes each). Information on the number of interacting proteins, level of sequence identity between human and insect, and additional structural properties is included.

Format: DOC Size: 118KB Download file

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Additional data file 9:

Presented is the ClustalW-based MSA of the family of SV2 in insects and a tree-like representation based on distances from the MSA.

Format: EPS Size: 848KB Download file