genomebiology.com

Table 1
Presynaptic protein prototypes
Number	Gene	Name	S	M

1	ADD2	β-Adducin	D
2	AMPH	Amphiphysin 1	D
3	AP2A1	AP-2 α-adaptin	A
4	AP3D1	AP-3 δ-adaptor	A
5	APBA1	Mint1	C
6	APBA2	Adapter protein X11β	B	*
7	ARF1	ARF 1	A
8	ARF6	ARF 6	A
9	ARFGEF2	ARF-GEF 2	B	*
10	ARFIP2	Arfaptin	B
11	ATP6V0C	ATPase 16 kDa	A
12	BAIAP3	Bai1-associated 3	D	*
13	BET1	Bet 1 homolog	B
14	BIN1	Bridging integrator 1	D
15	BLOC1S1	Lysosome BLOC1	B	*
16	BSN	Bassoon	E	*
17	CACNA1A	CaV2.1	B
18	CADPS	Caps	C	*
19	CALM2	Calmodulin	A
20	CASK	Lin-2 homolog	B
21	CLTC	Clathrin heavy chain	A
22	CNO	Cappuccino	D	*
23	CNTNAP1	Neurexin 4	D
24	CPLX2	Complexin 2	C
25	DLG1	SAP 97	B
26	DNAJC5	HSP40 homologue	B
27	DNM1	Dynamin 1	A
28	DOC2B	Double C2	C
29	EHD1	Testilin	A
30	EPN1	Epsin-1	C
31	EPS15	EGF substrate 15	D
32	ERC1	Rab6 interact CAST	D
33	EXOC6	Exocyst 6	C
34	EXPH5	Slp homolog	E	*
35	FLJ20366	Syntabulin	E	*
36	SNAP29	SNAP 29	D
37	GAP43	GAP 43	E	*
38	GDI2	Rab GDI 2	B
39	GMRP	P-selectin	D
40	GOPC	CFTR-associated ligand	C	*
41	GOSR2	Membrin	C
42	HGS	Hepatocyte TK subs	C
43	ITSN2	Intersectin	D
44	KIF1A	Kinesin family 1	B
45	LAMP1	Lysosomal 1	D
46	LIN7A	Mals-1	A
47	LPHN1	α-Latrotoxin receptor	D	*
48	MSS4	Rabif	C	*
49	MUTED	Muted	D	*
50	MYRIP	Rab-Myosin 7A	E	*
51	NET2	Tetraspanin-12	C
52	NLGN2	Neuroligin-2	D
53	NRXN1	Neurexin 1	D
54	NSF	NEM-sensitive fusion	B
55	PACSIN1	PKC and CK substrate	C	*
56	PCLO	Piccolo	D	*
57	PICALM	PI-binding clathrin	C
58	PIK4CA	P I4-kinase α	C
59	PIP5K1C	PI-4P 5-kinase 1γ	B
60	PLDN	Pallidin	D	*
61	PPFIA3	Liprin α 3	B
62	PSCD1	Cytohesin-1	A
63	PSCD2	Arno 2	B
64	RAB27A	Rab27A	B
65	RAB3A	Rab3A	A
66	RAB3GAP	Rab3 GTPase	D	*
67	RAB3IL1	Rabin 3	C	*
68	RAB6IP1	Rab6 interacting 1	C
69	RABAC1	YIP3 homolog	C
70	RABGAP1	Rab GTPase	C	*
71	RALA	Ral	A
72	RAPGEF4	Rap GEF 4	C
73	SEC22B	Sec22-like	B
74	RILP	Rab-interact	E	*
75	RIMBP2	RimS binding	D
76	RIMS1	Rims	D
77	RPH3A	Rabphilin 3A	C
78	SALF	Stoned B	D
79	SCAMP1	SCAMP37	C
80	SCIN	Scinderin	C	*
81	SEPT5	Septin 5	B
82	SH3GL1	Endophilin	C
83	SIPA1L1	Signal-proliferation 1	D
84	SLC17A7	VgluT1	C
85	SNAP25	SNAP-25	B
86	SNAP91	AP180	D
87	SNAPA	SNAP	B
88	SNAPAP	Snapin	C	*
89	SNIP	Snip	D	*
90	SNPH	Syntaphilin	E	*
91	SNX9	Sorting nexin	D	*
92	STX1A	Syntaxin	A
93	STXBP1	n-Sec	B
94	STXBP5	Tomosyn	C
95	STXBP6	Amisyn	E	*
96	SV2A	SV glycoprotein 1	D
97	SYBL1	Synaptobrevin-like	B
98	SYN	Synapsin	C
99	SYNGR1	Synaptogyrin	C	*
100	SYNJ1	Synaptojanin	C
101	SYNPR	Synaptoporin	E	*
102	SYP	Synaptophysin	E	*
103	SYT1	Synaptotagmin	B
104	SYT5	Synaptotagmin	B
105	SYT9	Synaptotagmin	C	*
106	SYTL4	Granulophilin	C	*
107	SYTL5	Synaptotagmin-like 5	D	*
108	TMEM163	synaptic vesicle31	E
109	TRAPPC1	Bet5 homolog	C
110	TRAPPC4	Sybindin	B
111	TXLNA	α-Taxilin	C	*
112	UNC13B	Munc-13	B	*
113	UNC13D	Unc-13 homolog	D
114	VAMP2	VAMP	A
115	VAPA	VAP33	C
116	VAT1	VAT-1	C	*
117	VPS18	Vacuolar sorting 18	D
118	VPS33B	Vps-33B	D
119	VTI1B	Vti1	D
120	YWHAQ	14-3-3 protein	A

The 120 presynaptic representatives from human (PS120) are indicated by their official gene names. Sequence conservation between human and insect proteomes is indicated by A to E. Sequence similarity index (S) is divided into five levels marked: A = >75%, B = >65%, C = >50%, D = >35%, and E = <34%. In the 'M' columns, an asterisk indicates that the gene is absent from the public protein databases. Detailed information on PS120 is provided in Additional data files 2a,2b.
Yanay et al. Genome Biology 2008 9:R27 doi:10.1186/gb-2008-9-2-r27

Table 1