Genome Biology

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Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication

Maria F Cardone1, Zhaoshi Jiang3,2, Pietro D'Addabbo1, Nicoletta Archidiacono1, Mariano Rocchi1, Evan E Eichler3,2 and Mario Ventura1*

Author Affiliations

1 Department of Genetics and Microbiology, University of Bari, Via Amendola, Bari, 70126, Italy

2 Department of Genome Sciences, University of Washington School of Medicine and the Howard Hughes Medical Institute, NE Pacific Street, Seattle, Washington, 98195, USA

3 Howard Hughes Medical Institute, NE Pacific Street, Seattle, Washington, 98195, USA

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Genome Biology 2008, 9:R28 doi:10.1186/gb-2008-9-2-r28

Published: 7 February 2008

Additional files

Additional data file 1:

Cat-specific BAC clones identified by library screening using overgo probes.

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Additional data file 2:

Additional human BAC clones used to define the inversion breakpoints in macaque.

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Additional data file 3:

Additional macaque BAC clones obtained by library screening or sequence analyses used to define the inversion breakpoints.

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Additional data file 4:

Each colored box indicates a different cluster of duplication detected by BAC clones: orange, BAC clone RP11-678G7 (Ed) from DUPA giving different hybridization patterns. See the text for details.

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Additional data file 5:

BAC clones from (a,b) DUPA' and (c,d) DUPB' on human (a,c) and macaque (b,d) metaphases. White arrows indicate chromosome 17 and the homologous regions in macaque.

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Additional data file 6:

Pairwise sequence similarity between putative breakpoints.

Format: XLS Size: 14KB Download file

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