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Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Tobias Warnecke email, Joanna L Parmley email and Laurence D Hurst email

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK

author email corresponding author email

Genome Biology 2008, 9:R29doi:10.1186/gb-2008-9-2-r29

Published: 7 February 2008

Subject areas: Evolution, Molecular biology, Bioinformatics


Additional files

Additional data file 1:

Amino acid trends for all species and associated statistics.

Format: XLS Size: 130KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 2:

Amino acid trends and associated statistics for homology-reduced gene sets of D. melanogaster and C. elegans.

Format: XLS Size: 50KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 3:

Protocol for homology reduction of C. elegans and D. melanogaster orthologues.

Format: DOC Size: 24KB Download file

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Additional data file 4:

Protocol for covariate analysis of abundance trends.

Format: DOC Size: 43KB Download file

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Additional data file 5:

Covariates of amino acid trends by species.

Format: XLS Size: 16KB Download file

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Additional data file 6:

By-species cross-correlations for covariates of amino acid trends.

Format: XLS Size: 33KB Download file

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Additional data file 7:

Best blast hits of SR proteins against C. neoformans genes and Pfam domain scores in those genes.

Format: TXT Size: 6KB Download file

Additional data file 8:

Analysis of ESE positioning in relation to the reading frame.

Format: DOC Size: 179KB Download file

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Additional data file 9:

Re-sampling distributions of evolutionary rates.

Format: DOC Size: 77KB Download file

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Additional data file 10:

Rank correlations between KA and the proportion of sequence near the exon-intron boundary.

Format: DOC Size: 32KB Download file

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Additional data file 11:

Detailed characterization of specific local discontinuities.

Format: DOC Size: 39KB Download file

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Additional data file 12:

Sources of exon datasets.

Format: DOC Size: 41KB Download file

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Additional data file 13:

Gene model IDs from which exons were derived.

Format: XLS Size: 5.8MB Download file

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Additional data file 14:

Examples of locally discontinuous preference trends.

Format: DOC Size: 64KB Download file

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Additional data file 15:

Local discontinuities across selected species.

Format: DOC Size: 75KB Download file

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