Research
Text-mining assisted regulatory annotation
-
* Corresponding authors: Stein Aerts stein.aerts@med.kuleuven.be - Casey M Bergman casey.bergman@manchester.ac.uk
1 Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, B-3000, Belgium
2 Department of Human Genetics, Katholieke Universiteit Leuven School of Medicine, Herestraat, Leuven, B-3000, Belgium
3 Institut de Neurosciences A Fessard, Centre National de la Rechere Scientifique, Gif-sur-Yvette, 91 198, France
4 Department of Electrical Engineering, Katholieke Universiteit Leuven, Heverlee, B-3001, Belgium
5 Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, V5Z 4E6, Canada
6 VIB Department for Molecular Biomedical Research, Ghent University, Ghent, 9052, Belgium
7 Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
8 Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Genome Biology 2008, 9:R31 doi:10.1186/gb-2008-9-2-r31
Published: 13 February 2008Abstract
Background
Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental analyses of regulatory networks and sequences rely heavily on positive control data from prior small-scale experiments, but the vast majority of previously discovered regulatory data remains locked in the biomedical literature.
Results
We develop text-mining strategies to identify relevant publications and extract sequence information to assist the regulatory annotation process. Using a vector space model to identify Medline abstracts from papers likely to have high cis-regulatory content, we demonstrate that document relevance ranking can assist the curation of transcriptional regulatory networks and estimate that, minimally, 30,000 papers harbor unannotated cis-regulatory data. In addition, we show that DNA sequences can be extracted from primary text with high cis-regulatory content and mapped to genome sequences as a means of identifying the location, organism and target gene information that is critical to the cis-regulatory annotation process.
Conclusion
Our results demonstrate that text-mining technologies can be successfully integrated with genome annotation systems, thereby increasing the availability of annotated cis-regulatory data needed to catalyze advances in the field of gene regulation.