Genome Biology

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Functional protein divergence in the evolution of Homo sapiens

Nuria Lopez-Bigas*, Subhajyoti De and Sarah A Teichmann

Genome Biology 2008, 9:R33 doi:10.1186/gb-2008-9-2-r33

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Conservation and divergence of known apicomplexan transcriptional regulons

Kobby Essien, Christian J Stoeckert BMC Genomics 2010, 11:147 (3 March 2010)

Transcription factors have diverged considerably between Plasmodium falciparum and other species of Apicomplexan parasites, as only three-fifths of the transcriptional networks are broadly conserved, and the associations between transcription factors and their target genes have changed.

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The conservation and evolutionary modularity of metabolism

José M Peregrín-Alvarez, Chris Sanford, John Parkinson Genome Biology 2009, 10:R63 (12 June 2009)

A novel evolutionary analysis of metabolic networks across 26 taxa reveals a highly-conserved but flexible core of metabolic enzymes.

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Co-evolutionary networks of genes and cellular processes across fungal species

Tamir Tuller, Martin Kupiec, Eytan Ruppin Genome Biology 2009, 10:R48 (5 May 2009)

Two new measures of evolution are used to study co-evolutionary networks of fungal genes and cellular processes; links between co-evolution and co-functionality are revealed.

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The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

Cinzia Di Pietro, Marco Ragusa, Davide Barbagallo, Laura R Duro, Maria R Guglielmino, Alessandra Majorana, Rosario Angelica, Marina Scalia, Luisa Statello, Loredana Salito, Luisa Tomasello, Salvo Pernagallo, Salvo Valenti, Vito D'Agostino, Patrizio Triberio, Igor Tandurella, Giuseppe A Palumbo, Piera La Cava, Viviana Cafiso, Taschia Bertuccio, Maria Santagati, Giovanni Li Destri, Salvatore Lanzafame, Francesco Di Raimondo, Stefania Stefani, Bud Mishra, Michele Purrello BMC Medical Genomics 2009, 2:20 (30 April 2009)

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Conservation of core gene expression in vertebrate tissues

Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009)

High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.

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Patterns of evolutionary constraints on genes in humans

Subhajyoti De, Nuria Lopez-Bigas, Sarah A Teichmann BMC Evolutionary Biology 2008, 8:275 (7 October 2008)