Table 1

Leishmania-secreted proteins associated with exosome-like and glycosomal vesicles

GeneDB accession number

Protein identificationa

Mean Cm/CA ratio

Microvesicle association


LmjF35.3340

6-Phosphogluconate dehydrogenase, decarboxylating, putative

3.01

GLY

LmjF29.0510

Cofilin-like protein

2.80

DC

LmjF36.6910

Chaperonin, putative, T-complex protein 1 (theta subunit), putative

2.61

AP

LmjF01.0770

Eukaryotic initiation factor 4a, putative

2.60

DC

LmjF28.2860

Cytosolic malate dehydrogenase, putative

2.20

AP

LmjF24.2060

Transketolase, putative

2.19

GLY

LmjF33.2550

Isocitrate dehydrogenase, putative

2.16

AP

LmjF28.2770

Heat-shock protein hsp70, putative

2.14

BC, DC, AP

LmjF35.3860

T-complex protein 1, eta subunit, putative

2.14

AP

LmjF12.0250

Cysteinyl-tRNA synthetase, putative

2.07

GLY

LmjF14.1160

Enolase

2.05

BC, DC, AP

LmjF36.2030

Chaperonin Hsp60, mitochondrial precursor

2.03

AP

LmjF23.1220

T-complex protein 1, gamma subunit, putative

2.00

AP

LmjF05.0350

Trypanothione reductase

1.99

GLY

LmjF36.2020

Chaperonin Hsp60, mitochondrial precursor

1.98

AP

LmjF36.1630

Clathrin heavy chain, putative

1.98

BC, AP

LmjF16.0540

Aspartate carbamoyltransferase, putative

1.95

GLY

LmjF27.2000

Hypothetical protein, conserved

1.90

GLY

LmjF31.1070

Biotin/lipoate protein ligase-like protein

1.89

AP

LmjF26.1240

Heat shock protein 70-related protein

1.86

BC, DC, AP

LmjF04.0960

Adenylate kinase, putative

1.77

GLY

LmjF27.1260

T-complex protein 1, beta subunit, putative

1.76

AP

LmjF30.3240

Glutamyl-tRNA synthetase, putative

1.74

GLY

LmjF21.0810

Methionyl-tRNA synthetase, putative

1.74

GLY

LmjF36.3210

14-3-3 Protein-like protein

1.74

DC, AP

LmjF33.2540

Carboxypeptidase, putative, metallo-peptidase

1.73

GLY


a The Mascot algorithm {2008 609/id} was used to identify the protein names and the GeneDB accession numbers [29]. Microvesicles: BC, B-cell lymphocyte exosome [38,62]; DC, dendritic cell exosome [24]; AP, adipocyte exosome (adiposome) [39]; and GLY, leishmania glycosome [42]. CA, cell associated; Cm, conditioned medium; Hsp, heat shock protein.

Silverman et al. Genome Biology 2008 9:R35   doi:10.1186/gb-2008-9-2-r35

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