Table 3

Highly enriched leishmania secreted proteins

GeneDB accession number

Protein identification^a

Mean Cm/CA ratio^b

Function^c

Predicted location^c

LmjF14.1360

Myo-inositol-1-phosphate synthase

3.93

Inositol biosynthesis [50]

Cytosol

LmjF23.0200

Endoribonuclease L-PSP (pb5), putative

3.91

Nuclease, mRNA cleavage

Cytosol

LmjF15.1203

60S acidic ribosomal protein P2

3.73

Translation [102]

Ribosome^d

LmjF35.2420

Phosphoinositide-binding protein, putative

3.51

Phosphoinositol binding, signal transduction

Cytosol^d

LmjF16.0140

Eukaryotic translation initiation factor 1A, putative

3.26

Translation

Cytosol, exosomes [24,38,39]

LmjF32.2180

Hypothetical protein, conserved

3.08

Translation initiation

Nucleus

LmjF11.0630

Aminopeptidase, putative, metallo-peptidase, Clan MF, Family M17

3.05

Proteolysis

Cytosol

LmjF35.3340

6-Phosphogluconate dehydrogenase, decarboxylating, putative

3.01

Glucose cataboloism

Cytosol

LmjF04.0310

Beta-fructofuranosidase, putative

2.93

Carbohydrate metabolism

Cytosol^d

LmjF36.3840

Glycyl tRNA synthetase, putative

2.87

Translation

Cytosol

^aThe Mascot algorithm {2008 609/id} was used to identify the protein names and the GeneDB accession numberes [29]. ^bMean of normalized, log normal (Ln) transformed conditioned medium (Cm)/cell associated (CA) peptide ratios for at least three of four experiments. ^cPutative functions and locations are derived from the GeneDB database {2007 238/id}unless otherwise noted. *Protein sequence contains an amino-terminal secretion signal peptide according to SignalP.

Silverman et al. Genome Biology 2008 9:R35   doi:10.1186/gb-2008-9-2-r35