Table 1 |
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|
Major pattern recognition receptors involved in the recognition of non-self nucleic acids |
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|
Receptor family |
Location |
Ligand |
Receptor |
Adaptor |
|
|
||||
|
Toll-like receptors (TLRs) |
Endosomes |
CpG DNA, abnormal DNA |
TLR9 |
MyD88 |
|
ssRNA |
TLR7/TLR8 |
MyD88 |
||
|
dsRNA |
TLR3 |
TRIF |
||
|
RIG-I-like receptors (RLRs) |
Cytosol |
5'-triphosphate ssRNA |
RIG-I |
IPS-1 |
|
dsRNA |
MDA5 |
IPS-1 |
||
|
dsRNA |
LGP2 |
IPS-1 |
||
|
dsDNA |
DAI |
Unknown |
||
|
Nod-like receptors (NLRs) |
Cytosol |
Bacterial and viral RNA |
Cryopyrin |
ASC |
|
|
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|
Chi and Flavell Genome Biology 2008 9:211 doi:10.1186/gb-2008-9-3-211 |
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