Genome Biology Volume 9 Issue 3 |
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MinireviewCytoplasmic dynein could be key to understanding neurodegenerationGareth T Banks and Elizabeth MC Fisher  Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK author email corresponding author email
Genome Biology 2008,
9:214doi:10.1186/gb-2008-9-3-214
Subject areas: Genetics, Medicine, Cell biology Abstract
A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase. |