Genome Biology

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Cross-kingdom patterns of alternative splicing and splice recognition

Abigail M McGuire*, Matthew D Pearson, Daniel E Neafsey and James E Galagan

Genome Biology 2008, 9:R50 doi:10.1186/gb-2008-9-3-r50

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Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3

Nikolai P Kandul, Mohamed AF Noor BMC Genetics 2009, 10:67 (19 October 2009)

Large introns in the Drosophila Bru-3 gene promote both alternative splicing by exon skipping and exon turnover during evolution, suggesting that large introns could be a reservoir of genetic diversity.

Research article   Open Access

Intronization, de-intronization and intron sliding are rare in Cryptococcus

Scott W Roy BMC Evolutionary Biology 2009, 9:192 (7 August 2009)

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Comparative analysis indicates that alternative splicing in plants has a limited role in functional expansion of the proteome

Edouard I Severing, Aalt DJ van Dijk, Willem J Stiekema, Roeland CHJ van Ham BMC Genomics 2009, 10:154 (9 April 2009)

Hypothesis   Open Access

Exon definition as a potential negative force against intron losses in evolution

Deng-Ke Niu Biology Direct 2008, 3:46 (13 November 2008)

If the splicing of pre-mRNAs is initiated by exon definition, an exon larger than a particular size may cause splicing errors . Intron loss that results in oversized exons may thus be deleterious and selected against.