Figure 2.

Autocatalytic synthesis of coenzymes in Synechocystis sp. (a) Coenzyme A. (b) NAD⁺. (c) Tetrahydrofolate. Autocatalytic metabolites involved in a reaction are indicated above the arrows. Dashed lines point to the reactions where the autocatalytic metabolites are involved in their own synthesis. See Additional data file 3 for the full names of metabolites.