Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

Bin Yan^{* 1} , Guang Chen^{* 2,3} , Kunal Saigal^1,4 , Xinping Yang¹ , Shane T Jensen⁵ , Carter Van Waes¹ , Christian J Stoeckert^3,6 and Zhong Chen¹

¹Head and Neck Surgery Branch, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA

²Department of Bioengineering, Smith Walk; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

³Center for Bioinformatics, Guardian Drive; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

⁴NIH-Pfizer Clinical Research Training Program Award; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

⁵Department of Statistics, The Wharton School, Walnut Street; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

⁶Department of Genetics, School of Medicine, Curie Boulevard; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA