Schematic of ESP. End sequencing and mapping of tumor genome fragments to the human genome provides information about structural rearrangements in tumors. A bacterial artificial chromosome (BAC) end sequence (BES) pair is a valid pair if distance between ends mapped on the normal human genome sequence and the orientation of these ends and are consistent with those for a BAC clone insert; otherwise, the BES pair is invalid. bp, base pairs; ESP, end sequencing profiling.
Raphael et al. Genome Biology 2008 9:R59 doi:10.1186/gb-2008-9-3-r59