Figure 4.

Recurrent rearrangement loci in the three breast cancer cell lines. (a,b) Four loci on 20q13.2-13.3 shared by MCF7 and BT474 and (c) a locus near to the ERBB2 amplicon shared by BT474 and SKBR3. Colored boxes indicate the breakpoint regions for different bacterial artificial chromosome (BAC) clones from MCF7 (blue), BT474 (red), and SKBR3 (green) as a custom track on the University of California, San Francisco (UCSC) genome browser. A breakpoint region is defined as the possible locations of a breakpoint that are consistent with all the BAC end sequence (BES) in the cluster; thus, shorter boxes indicate more precise breakpoint localization. Arrows give the strand of the mapped BES and thus point away from the fused region.