Figure 6.

Results of SNP identification in BAC end sequences. (a) The number of high quality isolated single nucleotide polymorphisms (SNPs) in uniquely mapped bacterial artificial chromosome (BAC) end sequences expressed per kilobase (blue). Each tumor sample has a significantly higher rate of SNPs compared with the normal library, whereas the ovarian library exhibits a rate significantly higher than the other tumor samples. Also shown is the fraction of SNPs not found in dbSNP124 (red). The ovarian library shows a significantly higher rate of these novel SNPs. (b) Mutational spectrum of SNPs for each of the samples. For C:G → T:A transitions and C:G → G:C transversions, the fraction at CpG dinucleotides is indicated in red and yellow, respectively.