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The impact of the neisserial DNA uptake sequences on genome evolution and stability

Todd J Treangen1, Ole Herman Ambur23, Tone Tonjum23 and Eduardo PC Rocha45*

Author Affiliations

1 Algorithms and Genetics Group, Department of Computer Science, Technical University of Catalonia, Jordi Girona Salgado, 1-3, E-08034 Barcelona, Spain

2 Centre for Molecular Biology and Neuroscience and Institute of Microbiology, University of Oslo, Rikshospitalet, NO-0027 Oslo, Norway

3 Centre for Molecular Biology and Neuroscience and Institute of Microbiology, Rikshospitalet Medical Centre, NO-0027 Oslo, Norway

4 Atelier de Bioinformatique, UPMC - University of Paris 06, 4, Pl Jussieu, 75005 Paris, France

5 Microbial Evolutionary Genomics Group, URA CNRS 2171, Institut Pasteur, 28 R. Dr Roux, 75015 Paris, France

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Genome Biology 2008, 9:R60  doi:10.1186/gb-2008-9-3-r60

Published: 26 March 2008

Additional files

Additional data file 1:

Details regarding genome alignment

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Additional data file 2:

The average nucleotide distance between DUSs

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Additional data file 3:

The under-representation of DUSs in strain-specific insertions

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Additional data file 4:

The classification of polymorphic sites

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Additional data file 5:

The distribution of the distance between contiguous composite DUSs in the N. meningitidis Z2491 genome

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Additional data file 6:

A visual representation of M-GCAT's multiple alignment of four H. influenzae genomes

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Additional data file 7:

This data shows that within the core genome of H. influenzae the USS-proximal regions accumulate more substitutions

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Open Data