Reduced reliance on the trace element selenium during evolution of mammals

Alexey V Lobanov¹ , Dolph L Hatfield² and Vadim N Gladyshev¹

¹Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA

²Section on the Molecular Biology of Selenium, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

author email corresponding author email

Genome Biology 2008, 9:R62doi:10.1186/gb-2008-9-3-r62


Published:	31 March 2008

Subject areas: Biochemistry and structural biology, Evolution, Medicine

Additional files

Additional data file 1:

Figure S1 shows a search procedure for sequences containing two SECIS elements. Figure S2 features a multiple alignment of vertebrate SelP sequences. Figure S3 shows partial alignment of fish and mammalian SelP sequences. Figure S4 is a plot of selenoproteome size versus Sec content of SelPs. Figure S5 shows recent Sec/Cys changes in SelP sequences. Figure S6 provides an example of evolution of new Sec residues by carboxy-terminal extension. Figure S7 shows an in silico expression profile of SelP. Figure S8 is a plot of Cys content versus Sec content of SelPs

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