Table 1 |
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|
Genetic loci associated with disease and phenotypic variation |
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|
Disease type |
Disease |
Associated loci |
Date of publication |
Reference |
|
|
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|
Cancer |
Acute lymphoblastic leukemia |
PAX5 and others |
12 April 2007 |
[40] |
|
Breast cancer |
FGFR2, TNCR9, MAP3K1, LSP and others |
27 May 2007 |
[41] |
|
|
Colon, prostate cancer |
8q24 |
8 July 2007 |
[42-44] |
|
|
Colorectal cancer |
SMAD7 |
14 October 2007 |
[45] |
|
|
CRAC1 (HMPS) |
16 December 2007 |
[46] |
||
|
Multiple solid tumors |
CASP8 |
22 April 2007 |
[47] |
|
|
Prostate cancer |
8q24 |
1 April 2007 |
[48,49] |
|
|
TCF2; 17p |
1 July 2007 |
[50] |
||
|
2p15, Xp11.22 and multiple others |
10 February 2008 |
[51-53] |
||
|
Heart |
Myocardial infarction, coronary artery disease, intracranial aneurysm |
9p21 |
6 January 2008 |
[26] |
|
9p21 |
3 May 2007 |
[26,54] |
||
|
6q25, 2q36 |
18 July 2007 |
[28] |
||
|
Atrial fibrillation |
4q25 |
1 July 2007 |
[55] |
|
|
Metabolic |
Celiac disease |
IL-2, IL-21 |
10 June 2007 |
[56] |
|
Diabetes, type 1 |
12q24 and others |
6 June 2007 |
[57] |
|
|
KIAA0350 |
15 July 2007 |
[37] |
||
|
IL2RA |
5 August 2007 |
[58] |
||
|
Diabetes, type 2 |
CDKAL1 and six others |
26 April 2007 |
[59,60] |
|
|
WFS1 |
1 July 2007 |
[61] |
||
|
Gout |
SLCA9 |
9 March 2008 |
[23,24] |
|
|
Hypercholesterolemia |
CELSR2 |
9 February 2008 |
[62] |
|
|
Lipoprotein disorders |
MLX1PL and multiple others |
13 January 2008 |
[32,62,63] |
|
|
Obesity |
FTO |
12 April 2007 |
[31] |
|
|
Neurodegenerative |
Amyotrophic lateral sclerosis |
FLJ10986 |
1 August 2007 |
[64] |
|
DPP6 |
16 December 2007 |
[65] |
||
|
Multiple sclerosis |
IL7Rα, IL2Rα |
28 July 2007 |
[66-68] |
|
|
Immune mediated |
Ankylosing spondylitis |
ARTS1, IL23R |
21 October 2007 |
[69] |
|
Autoimmune thyroid disease |
TSHR, FCRL3 |
21 October 2007 |
[69] |
|
|
Rheumatoid arthritis |
6p21, 1p13 |
7 June 2007 |
[22] |
|
|
TRAF1-C5 |
31 August 2007 |
[70] |
||
|
6q23 |
4 Nov 2007 |
[71,72] |
||
|
Systemic lupus erythematosus |
TNFSF4 |
2 December 2007 |
[73] |
|
|
PXK, KIAA1542, BANK1, C8orf-BLK, ITGAM |
20 January 2008 |
[74-77] |
||
|
Age-related macular degeneration |
C3 |
18 July 2007 |
[78] |
|
|
Celiac disease |
IL-2, IL-21 |
10 June 2007 |
[56] |
|
|
Other |
Asthma (childhood) |
ORMDL3 |
4 July 2007 |
[79] |
|
Bipolar disorder |
16p12 |
7 June 2007 |
[22] |
|
|
Crohn's disease |
IRGM |
6 June 2007 |
[80] |
|
|
ILR23 |
26 October 2006 |
[81] |
||
|
IBD5 |
October 2001 |
[82] |
||
|
ATG16L1 |
15 April 2007 |
[83,84] |
||
|
5p13.1 |
5 March 2007 |
[85] |
||
|
NOD2 |
16 June 2001 |
[86] |
||
|
Gallstone disease |
ABCG8 |
15 July 2007 |
[87] |
|
|
Glaucoma |
LOXL1 |
9 August 2007 |
[88] |
|
|
HIV host control |
HLA-B*5701 |
19 July 2007 |
[89] |
|
|
Psoriasis |
β-Defensin, CNV |
2 December 2007 |
[90] |
|
|
Restless leg syndrome |
MEIS1, BTBD9, MAP2K5 |
18 July 2007 |
[91] |
|
|
|
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Rahim et al. Genome Biology 2008 9:215 doi:10.1186/gb-2008-9-4-215 |
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