The AAA+ superfamily of functionally diverse proteins

Jamie Snider^*, Guillaume Thibault^* and Walid A Houry

Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada

author email corresponding author email* Contributed equally

Genome Biology 2008, 9:216doi:10.1186/gb-2008-9-4-216


Published:	30 April 2008

Subject areas: Biochemistry and structural biology, Cell biology

Abstract

The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module.