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New tricks for old NODs

Eric M Pietras1 and Genhong Cheng123*

Author Affiliations

1 Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA

2 Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA

3 Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA

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Genome Biology 2008, 9:217  doi:10.1186/gb-2008-9-4-217

Published: 25 April 2008

Abstract

Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and the questions and implications they raise regarding the function of NOD-like receptors in the antiviral response.