New tricks for old NODs
1 Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA
2 Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
3 Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA
Genome Biology 2008, 9:217 doi:10.1186/gb-2008-9-4-217
Published: 25 April 2008Abstract
Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and the questions and implications they raise regarding the function of NOD-like receptors in the antiviral response.
