New tricks for old NODs

Eric M Pietras¹ and Genhong Cheng¹^,2^,3

¹Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA

²Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA

³Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA

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Genome Biology 2008, 9:217doi:10.1186/gb-2008-9-4-217


Published:	25 April 2008

Subject areas: Virology, Immunology, Cell biology, Medicine

Abstract

Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and the questions and implications they raise regarding the function of NOD-like receptors in the antiviral response.