ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?
1 Department of Molecular and Developmental Genetics, VIB, Herestraat 49, B-3000 Leuven, Belgium
2 Department of Human Genetics, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium
3 Bioinformatics group, Department of Electrical Engineering (ESAT-SCD), University of Leuven, Kasteelpark Arenberg, B-3001 Heverlee, Belgium
Genome Biology 2008, 9:R66 doi:10.1186/gb-2008-9-4-r66Published: 7 April 2008
We present ModuleMiner, a novel algorithm for computationally detecting cis-regulatory modules (CRMs) in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data, and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly, CRM predictions for differentiated tissues exhibit strong enrichment close to the transcription start site, whereas CRM predictions for embryonic development gene sets are depleted in this region.