Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective

Jinfeng Liu¹ , Yan Zhang¹ , Xingye Lei² and Zemin Zhang¹

¹Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA

²Department of Biostatistics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA

author email corresponding author email

Genome Biology 2008, 9:R69doi:10.1186/gb-2008-9-4-r69


Published:	8 April 2008

Subject areas: Evolution, Genome studies

Additional files

Additional data file 1:

Table S1 presents correlation and partial correlations between SNP A/S ratios and expression parameters. Figure S1 shows an example of using Monte Carlo sampling to get the same distributions of expression breadth for different groups of proteins. Figure S2 and S3 demonstrate that for most variables in our study, the differences in A/S ratios between groups do not change qualitatively after controlling for expression breadth.

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