Research
Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective
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* Corresponding author: Zemin Zhang zemin@gene.com
1 Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
2 Department of Biostatistics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
Genome Biology 2008, 9:R69 doi:10.1186/gb-2008-9-4-r69
Published: 8 April 2008Additional files
Additional data file 1:
Table S1 presents correlation and partial correlations between SNP A/S ratios and expression parameters. Figure S1 shows an example of using Monte Carlo sampling to get the same distributions of expression breadth for different groups of proteins. Figure S2 and S3 demonstrate that for most variables in our study, the differences in A/S ratios between groups do not change qualitatively after controlling for expression breadth.
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