Research
Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling
1 International NRW Graduate School in Bioinformatics and Genome Research, Bielefeld University, D-33594 Bielefeld, Germany
2 Fermentation Engineering Group, Bielefeld University, D-33594 Bielefeld, Germany
3 Faculty of Biology, Bielefeld University, D-33594 Bielefeld, Germany
Genome Biology 2008, 9:R72 doi:10.1186/gb-2008-9-4-r72
Published: 10 April 2008Additional files
Additional data file 1:
Presented is a table listing the identified metabolites of the ancestral and evolved strains by gas chromatography-mass spectrometry.
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Additional data file 2:
Presented is a table listing significantly altered metabolites in all of the evolved conditions.
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Additional data file 3:
Presented is a table listing significantly altered genes in all of the evolved conditions.
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Additional data file 4:
Presented is a table listing significant GO functional categories involved in all of the evolved conditions.
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Additional data file 5:
Presented is a figure showing the integration of transcriptome and metabolome data during the comparison of ancestral and evolved strains in excess nutrient adaptive evolution.
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Additional data file 6:
Presented is a figure showing the gene expression and metabolite abundance level in the pentose phosphate pathway in excess nutrient adapted strains.
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Additional data file 7:
Presented is a figure showing PCA analyses for both the ancestor and evolved lines of both strains grown in two different media.
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Additional data file 8:
Presented is a table listing common topologic properties of all evolution co-expression networks.
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Additional data file 9:
Presented is a figure showing the gene expression and metabolite abundance level in histidine biosynthesis pathway in excess nutrient adapted strains.
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Additional data file 10:
Presented is a figure showing the integration of transcriptome and metabolome data during the comparison of ancestral and evolved strains in prolonged stationary phase evolution.
Format: PDF Size: 2.7MB Download file
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Additional data file 11:
Presented is a figure showing metabolite abundance level and gene expression level among the biologic replicates.
Format: PDF Size: 530KB Download file
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