Genome Biology
Volume 9
Issue 4

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Vijayendran C
Barsch A
Friehs K
Niehaus K
Becker A
Flaschel E

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Barsch A
Friehs K
Niehaus K
Becker A
Flaschel E
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Research

Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling

Chandran Vijayendran¹^,2 , Aiko Barsch³ , Karl Friehs² , Karsten Niehaus³ , Anke Becker³ and Erwin Flaschel²

¹International NRW Graduate School in Bioinformatics and Genome Research, Bielefeld University, D-33594 Bielefeld, Germany

²Fermentation Engineering Group, Bielefeld University, D-33594 Bielefeld, Germany

³Faculty of Biology, Bielefeld University, D-33594 Bielefeld, Germany

author email corresponding author email

Genome Biology 2008, 9:R72doi:10.1186/gb-2008-9-4-r72


Published:	10 April 2008

Subject areas: Evolution, Genome studies, Microbiology and parasitology

Additional files

Additional data file 1:

Presented is a table listing the identified metabolites of the ancestral and evolved strains by gas chromatography-mass spectrometry.

Format: PDF Size: 62KB Download file

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Additional data file 2:

Presented is a table listing significantly altered metabolites in all of the evolved conditions.

Format: PDF Size: 45KB Download file

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Additional data file 3:

Presented is a table listing significantly altered genes in all of the evolved conditions.

Format: PDF Size: 130KB Download file

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Additional data file 4:

Presented is a table listing significant GO functional categories involved in all of the evolved conditions.

Format: PDF Size: 64KB Download file

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Additional data file 5:

Presented is a figure showing the integration of transcriptome and metabolome data during the comparison of ancestral and evolved strains in excess nutrient adaptive evolution.

Format: PDF Size: 2.8MB Download file

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Additional data file 6:

Presented is a figure showing the gene expression and metabolite abundance level in the pentose phosphate pathway in excess nutrient adapted strains.

Format: PDF Size: 418KB Download file

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Additional data file 7:

Presented is a figure showing PCA analyses for both the ancestor and evolved lines of both strains grown in two different media.

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Additional data file 8:

Presented is a table listing common topologic properties of all evolution co-expression networks.

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Additional data file 9:

Presented is a figure showing the gene expression and metabolite abundance level in histidine biosynthesis pathway in excess nutrient adapted strains.

Format: PDF Size: 461KB Download file

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Additional data file 10:

Presented is a figure showing the integration of transcriptome and metabolome data during the comparison of ancestral and evolved strains in prolonged stationary phase evolution.

Format: PDF Size: 2.8MB Download file

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Additional data file 11:

Presented is a figure showing metabolite abundance level and gene expression level among the biologic replicates.

Format: PDF Size: 530KB Download file

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