RNA polymerase II stalling: loading at the start prepares genes for a sprint
1 Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, New Haven, CT 06511, USA
2 Molecular Biophysics and Biochemistry Department, Yale University, PO Box 208103, New Haven, CT 06511, USA
Genome Biology 2008, 9:220 doi:10.1186/gb-2008-9-5-220Published: 2 May 2008
Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received.