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Highly Accessed Review

RNA polymerase II stalling: loading at the start prepares genes for a sprint

Jia Qian Wu1 and Michael Snyder12*

Author Affiliations

1 Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, New Haven, CT 06511, USA

2 Molecular Biophysics and Biochemistry Department, Yale University, PO Box 208103, New Haven, CT 06511, USA

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Genome Biology 2008, 9:220  doi:10.1186/gb-2008-9-5-220

Published: 2 May 2008

Abstract

Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received.