Genome Biology
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 ReviewRNA polymerase II stalling: loading at the start prepares genes for a sprintJia Qian Wu1 and Michael Snyder1,2  1
Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, New Haven, CT 06511, USA 2
Molecular Biophysics and Biochemistry Department, Yale University, PO Box 208103, New Haven, CT 06511, USA  author email corresponding author email
Genome Biology 2008,
9:220doi:10.1186/gb-2008-9-5-220
Subject areas: Genetics, Genome studies, Molecular biology Abstract
Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received. | 
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