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CpG island density and its correlations with genomic features in mammalian genomes

Leng Han1,2,3 email, Bing Su2,4 email, Wen-Hsiung Li5 email and Zhongming Zhao1,6 email

1Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA

2State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

3Graduate School, Chinese Academy of Sciences, Beijing 100039, China

4Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

5Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA

6Department of Human Genetics and Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284, USA

author email corresponding author email

Genome Biology 2008, 9:R79doi:10.1186/gb-2008-9-5-r79

Published: 13 May 2008

Subject areas: Molecular biology, Genome studies, Evolution


Additional files

Additional file 1:

Numbers of genes estimated in mammalian genomes.

Format: PDF Size: 27KB Download file

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Additional file 2:

Correlations between CGI density and genomic features in ten mammalian genomes (including platypus).

Format: PDF Size: 20KB Download file

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Additional file 3:

Correlations between intergenic CGI density and genomic features in nine mammalian genomes.

Format: PDF Size: 21KB Download file

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Additional file 4:

Correlations between CGI density and average recombination rate (cM/Mb) in the human, mouse and rat genomes.

Format: PDF Size: 41KB Download file

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Additional file 5:

Comparison of CpG islands and other genomic features between mammalian and non-mammalian genomes.

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Additional file 6:

Correlations between CGI density and genomic features in mammalian genomes using the Gardiner-Garden and Frommer algorithm in the non-repeat portions of genomes. In both Additional data files 6 and 7, the platypus chromosomes were excluded because of incomplete genome sequence data and chromosome data. The conclusion would be the same when the platypus data were included.

Format: PDF Size: 20KB Download file

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Additional file 7:

Correlations between CGI density and genomic features in mammalian genomes using the CpGcluster algorithm. In both Additional data files 6 and 7, the platypus chromosomes were excluded because of incomplete genome sequence data and chromosome data. The conclusion would be the same when the platypus data were included.

Format: PDF Size: 19KB Download file

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Additional file 8:

The first sheet ('overview') summarizes the total number of CGIs in each genome identified by each algorithm. The length distribution of CGIs in each genome is shown in each additional sheet.

Format: XLS Size: 43KB Download file

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Additional file 9:

Body temperature and lifespan for each species.

Format: XLS Size: 26KB Download file

This file can be viewed with: Microsoft Excel Viewer


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