Table 2 |
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|
Aging-associated probe sets that are differentially expressed in wounds from elderly compared to young subjects |
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| Affy ID |
Gene* |
Gene (description) |
Function |
q-value† |
FC‡ |
|
|
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| Down-regulated probe sets (12) |
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| 217496_s_at |
IDE§ |
insulin-degrading enzyme |
Wound fluid/resolution of insulin response |
4.0E-06 |
-20.5 |
| 210074_at |
CTSL2§ |
cathepsin L2 |
Lysosomal cysteine proteinase |
3.8E-05 |
-15.5 |
| 214131_at |
SERPINB13 |
serpin peptidase inhibitor, clade B (ovalbumin), member 13 |
UV-responsive proteinase inhibitor |
1.1E-03 |
-15.0 |
| 214131_at |
C12orf5 |
chromosome 12 open reading frame 5 |
Protection from DNA damage |
1.1E-03 |
-12.8 |
| 204733_at |
KLK6§ |
kallikrein 6 (neurosin, zyme) |
Hormone regulated serine protease |
1.4E-05 |
-11.9 |
| 202179_at |
BLMH§ |
bleomycin hydrolase |
Alzheimer's-associated cysteine peptidase |
2.1E-03 |
-11.8 |
| 210338_s_at |
HSPA8§ |
heat shock 70 kDa protein 8 |
Aging-associated heat shock protein |
9.9E-04 |
-10.6 |
| 201849_at |
BNIP3§ |
BCL2/adenovirus E1B 19 kDa interacting protein 3 |
Mitochondrial apoptosis-inducing |
2.7E-04 |
-10.1 |
| 203328_x_at |
IDE§ |
insulin-degrading enzyme |
Wound fluid/resolution of insulin response |
1.4E-05 |
-17.4 |
| 203327_at |
IDE§ |
insulin-degrading enzyme |
Wound fluid/resolution of insulin response |
7.0E-04 |
-9.3 |
| 205016_at |
TGFA§ |
transforming growth factor, alpha |
IFN-induced/epidermal regeneration |
1.0E-03 |
-8.5 |
| 212907_at |
SLC30A1 |
Solute carrier family 30 (zinc transporter), member 1 |
Zinc/calcium ion transporter |
8.5E-04 |
-7.3 |
|
|
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|
*Genes in bold have been validated by qPCR. †CyberT-derived multiple testing corrected q-value. ‡Fold change (old/young). §Also estrogen-regulated (Table 1). |
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|
Hardman and Ashcroft Genome Biology 2008 9:R80 doi:10.1186/gb-2008-9-5-r80 |
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