Table 1

Candidate genes whose expression is altered in the cancer stem cell population
Gene description
 Symbol
 Stem versus committed*
 Malignant versus benign*
Pregnancy-associated plasma protein A, pappalysin 1
 PAPPA
 3.83
 3.26
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
 NFKB1
 2.30
 1.86
Tight junction protein 2 (zona occludens 2)
 TJP2
 2.51
 1.72
Abl-interactor 1
 ABI1
 3.41
 1.84
B-cell translocation gene 1, anti-proliferative
 BTG1
 3.95
 1.53
Interleukin 6 (interferon, beta 2)
 IL6
 1.93
 5.18
CASP8 and FADD-like apoptosis regulator
 CFLAR
 1.90
 1.41
Smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
 SMU1
 1.90
 1.63
S100 calcium binding protein A3
 S100A3
 1.92
 1.55
Chromosome 17 open reading frame 27
 C17orf27
 1.63
 1.80
RAS and EF-hand domain containing
 RASEF
 2.31
 1.71
Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
 ITGAV
 2.55
 1.62
Interferon gamma receptor 1
 IFNGR1
 1.70
 1.46




Insulin growth factor-like family member 1
 IGFL1
 -1.17
 -28.61
Microseminoprotein, beta- (PSP94)
 MSMB
 -27.78
 -2.84
Prostate stem cell antigen
 PSCA
 -20.11
 -2.27
Carcinoembryonic antigen-related cell adhesion molecule 5
 CEACAM5
 -19.12
 -1.77
S100 calcium binding protein A7 (psoriasin 1)
 S100A7
 -11.48
 2.28
Hydroxyprostaglandin dehydrogenase 15-(NAD)
 HPGD
 -8.54
 -2.41
Carcinoembryonic antigen-related cell adhesion molecule 7
 CEACAM7
 -19.22
 2.95
Trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)
 TFF1
 -11.74
 -2.25
Prolactin-induced protein
 PIP
 -17.42
 1.04

*Values are mean fold expression changes abstracted from Affymetrix datasets. Positive values (top half) indicate over expression in the cancer stem cell samples. Negative values (bottom half) indicate genes over-expressed in the committed cell or benign cell fractions.

Birnie et al. Genome Biology 2008 9:R83   doi:10.1186/gb-2008-9-5-r83

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