Genome Biology

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Sequence-based prediction of protein-protein interactions by means of codon usage

Hamed S Najafabadi1,2 and Reza Salavati1,2,3*

Author Affiliations

1 Institute of Parasitology, McGill University, Lakeshore Road, Ste. Anne de Bellevue, Montreal, Quebec H9X 3V9, Canada

2 McGill Centre for Bioinformatics, McGill University, University Street, Montreal, Quebec H3A 2B4, Canada

3 Department of Biochemistry, McGill University, Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada

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Genome Biology 2008, 9:R87 doi:10.1186/gb-2008-9-5-r87

Published: 23 May 2008

Additional files

Additional data file 1:

Distribution of d for each codon in yeast.

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Additional data file 2:

Comparison of the naïve Bayesian network and fully connected Bayesian network in the yeast gold standard positive set.

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Additional data file 3:

Comparison of the naïve Bayesian network and fully connected Bayesian network in the yeast gold standard negative set.

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Additional data file 4:

Variance over different components resulting from principal component analysis of the interacting gene pairs in yeast.

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Additional data file 5:

Comparison of PIC, PI-RSCU, PI-A and PI-L.

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Additional data file 6:

Comparison of PIP × PIC and the yeast gold standard positive set.

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Additional data file 7:

Per-complex comparison of PIP and PIP × PIC.

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Additional data file 8:

MIPS functional category enrichment for the yeast genome, PIP-Lcut600 and PIC-Lcut600.

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Additional data file 9:

Distribution of mRNA expression levels in interactions predicted by PIP-Lcut600 and PIC-Lcut600 for S. cerevisiae.

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Additional data file 10:

precision-recall curves for PIC, interolog mapping (INT), phylogenetic profiles (PGP), Rosetta stone (ROS), CAI coevolution (co-CAI) and CAI.

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Additional data file 11:

Precision-recall curves for PIC, PIT and PICT.

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Additional data file 12:

PIC-Lcut600 for S. cerevisiae.

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Additional data file 13:

PICT-Lcut2000 for S. cerevisiae.

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Additional data file 14:

Results of performance of PIC on the P. falciparum gold standard set. For the performance of PIC on Escherichia coli gold standard set check reference [23].

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