Genome Biology

official impact factor 6.89

Open Access Research

Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice

Jonathan M Mudge1*, Stuart D Armstrong2, Karen McLaren1, Robert J Beynon2, Jane L Hurst3, Christine Nicholson1, Duncan H Robertson2, Laurens G Wilming1 and Jennifer L Harrow1

Author Affiliations

1 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2 Proteomics and Functional Genomics Group, Department of Veterinary Preclinical Science, University of Liverpool, Crown Street and Brownlow Hill, Liverpool, L69 7ZJ, UK

3 Mammalian Behavior and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst, Neston, CH64 7TE, UK

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Genome Biology 2008, 9:R91 doi:10.1186/gb-2008-9-5-r91

Published: 28 May 2008

Additional files

Additional data file 1:

Alignment of the B6 and S7 MUPs.

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Additional data file 2:

The point of alignment inversion is seen to correspond to the location of a murine ERV.

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Additional data file 3:

Dot-plot comparison of the mass 18,893-associated duplication from the B6 genome.

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Additional data file 4:

Details of the absence of MUP isoforms in the upper mass range of ESI-MS spectra of inbred mouse urine samples.

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Additional data file 5:

Individual variation in ESI-MS mass spectra of MUP isoforms in urine.

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Additional data file 6:

Increasing the volume of urine loaded onto a native PAGE gel does not change the banding pattern observed once the essential banding pattern has become visible.

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