Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

Edward K Lobenhofer¹ , J Todd Auman^2,11 , Pamela E Blackshear³ , Gary A Boorman⁴ , Pierre R Bushel⁵ , Michael L Cunningham⁴ , Jennifer M Fostel^6,7 , Kevin Gerrish² , Alexandra N Heinloth² , Richard D Irwin⁴ , David E Malarkey⁸ , B Alex Merrick⁷ , Stella O Sieber² , Charles J Tucker² , Sandra M Ward⁸ , Ralph E Wilson⁸ , Patrick Hurban¹ , Raymond W Tennant^{* 9} and Richard S Paules^{* 10}

¹Cogenics, a Division of Clinical Data, Inc., Morrisville, NC 27560, USA

²NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

³Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27709, USA

⁴National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

⁵Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

⁶National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

⁷Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

⁸Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

⁹Cancer Biology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

¹⁰Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709

¹¹Current address: Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA