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Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

Edward K Lobenhofer1*, J Todd Auman112, Pamela E Blackshear3, Gary A Boorman4, Pierre R Bushel5, Michael L Cunningham4, Jennifer M Fostel67, Kevin Gerrish2, Alexandra N Heinloth2, Richard D Irwin4, David E Malarkey8, B Alex Merrick7, Stella O Sieber2, Charles J Tucker2, Sandra M Ward8, Ralph E Wilson8, Patrick Hurban1, Raymond W Tennant9 and Richard S Paules10*

Author Affiliations

1 Cogenics, a Division of Clinical Data, Inc., Morrisville, NC 27560, USA

2 NIEHS Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

3 Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27709, USA

4 National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

5 Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

6 National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

7 Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

8 Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

9 Cancer Biology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

10 Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709

11 Current address: Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

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Genome Biology 2008, 9:R100  doi:10.1186/gb-2008-9-6-r100

Published: 20 June 2008

Additional files

Additional data file 1:

Histopathological scores as well as the clinical chemistry and hematology data that were generated for each animal in this project.

Format: ZIP Size: 165KB Download file

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Additional data file 2:

Agilent probe identifiers that resulted from the SVM analyses detailed in the Results section.

Format: ZIP Size: 38KB Download file

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Additional data file 3:

Enrichment p-values that resulted from performing a GO enrichment analysis on the list of classifiers for each dose/time/tissue group. GO categories must have had at least five associated genes measured on the microarray in order to be included.

Format: XLS Size: 564KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 4:

Observations and measurements made during the in-life portion of the project.

Format: ZIP Size: 40KB Download file

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Additional data file 5:

Scoring method used for the histopathological observations made in this project.

Format: DOCX Size: 15KB Download file

Open Data