Table 1

Hepatotoxicants studied
Compound
 Low dose 'sub-toxic' (mg/kg)
 Medium dose 'moderately toxic' (mg/kg)
 Medium high dose (mg/kg)
 High dose 'toxic' (mg/kg)
 Vehicle
 Delivery method
 Primary site of livery injury
Bromobenzene
 25
 75
 NA
 250
 Corn oil
 Oral gavage
 Centrilobular
1,2-Dichlorobenzene
 15
 150
 NA
 1,500
 Corn oil
 Oral gavage
 Centrilobular
1,4-Dichlorobenzene
 15
 150
 NA
 1,500
 Corn oil
 Oral gavage
 NA*
N-nitrosomorpholine
 10
 50
 NA
 300
 PBS
 Oral gavage
 Centrilobular
Diquat
 5
 10
 20
 25
 PBS
 Intraperitoneal injection
 Mid-zonal to centrilobular
Monocrotaline
 10
 50
 NA
 300
 PBS
 Oral gavage
 Centrilobular
Thioacetamide
 15
 50
 NA
 150
 PBS
 Oral gavage
 Centrilobular
Galactosamine
 25
 100
 NA
 400
 PBS
 Intra-peritoneal injection
 Random

*1, 4-Dichlorobenzene was intended to function as a non-toxic analog of 1,2-dichlorobenezene; however, centrilobular hepatocyte necrosis was observed in one of the six low dose animals at 6 hours and all four of the high dose animals at the 24 hour time point. NA, not applicable; PBS, phosphate-buffered saline.

Lobenhofer et al. Genome Biology 2008 9:R100   doi:10.1186/gb-2008-9-6-r100

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