Table 1

Hepatotoxicants studied

Compound

Low dose 'sub-toxic' (mg/kg)

Medium dose 'moderately toxic' (mg/kg)

Medium high dose (mg/kg)

High dose 'toxic' (mg/kg)

Vehicle

Delivery method

Primary site of livery injury


Bromobenzene

25

75

NA

250

Corn oil

Oral gavage

Centrilobular

1,2-Dichlorobenzene

15

150

NA

1,500

Corn oil

Oral gavage

Centrilobular

1,4-Dichlorobenzene

15

150

NA

1,500

Corn oil

Oral gavage

NA*

N-nitrosomorpholine

10

50

NA

300

PBS

Oral gavage

Centrilobular

Diquat

5

10

20

25

PBS

Intraperitoneal injection

Mid-zonal to centrilobular

Monocrotaline

10

50

NA

300

PBS

Oral gavage

Centrilobular

Thioacetamide

15

50

NA

150

PBS

Oral gavage

Centrilobular

Galactosamine

25

100

NA

400

PBS

Intra-peritoneal injection

Random


*1, 4-Dichlorobenzene was intended to function as a non-toxic analog of 1,2-dichlorobenezene; however, centrilobular hepatocyte necrosis was observed in one of the six low dose animals at 6 hours and all four of the high dose animals at the 24 hour time point. NA, not applicable; PBS, phosphate-buffered saline.

Lobenhofer et al. Genome Biology 2008 9:R100   doi:10.1186/gb-2008-9-6-r100

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