Table 3 |
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|
Mouse SuperArray data showing greater than twofold cell stress RNA expression changes in the cerebellum of Wlds mice compared with wild-type controls |
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|
Gene name |
Symbol |
Acc. number |
Array cell |
Fold change |
SD |
Cell stress and toxicity function |
|
|
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|
Serine (or cysteine) peptidase inhibitor, clade E, member 1 |
Serpine1 |
G01 |
3.73 |
0.29 |
Inflammation |
|
|
Interleukin 1 beta |
Il1b |
E11 |
3.69 |
0.82 |
Inflammation |
|
|
Transformed mouse 3T3 cell double minute 2 |
Mdm2 |
F02 |
3.34 |
0.15 |
Growth arrest and senescence |
|
|
Cytochrome P450, family 2, subfamily a, polypeptide 5 |
Cyp2a5 |
B08 |
2.92 |
0.48 |
Oxidative or metabolic stress |
|
|
Fas ligand (TNF superfamily, member 6) |
Fasl |
C11 |
2.62 |
0.71 |
Apoptosis signaling |
|
|
Bcl2-like 1 |
Bcl2l1 |
A04 |
-2.11 |
0.25 |
Apoptosis signaling |
|
|
Cyclin C |
Ccnc |
A10 |
-2.44 |
0.46 |
Proliferation and carcinogenesis |
|
|
Chemokine (C-C motif) ligand 21b |
Ccl21b |
A07 |
-3.37 |
0.25 |
Inflammation |
|
|
Chemokine (C-C motif) ligand 4 |
Ccl4 |
A09 |
-3.86 |
0.40 |
Inflammation |
|
|
Annexin A5 |
Anxa5 |
A01 |
-4.00 |
1.50 |
Apoptosis signaling |
|
|
Ataxia telangiectasia mutated homolog (human) |
Atm |
A02 |
-4.99 |
0.70 |
DNA damage and repair |
|
|
Caspase 1 |
Casp1 |
A05 |
-6.81 |
7.58 |
Apoptosis signaling |
|
|
Cytochrome P450, family 3, subfamily a, polypeptide 11 |
Cyp3a11 |
B12 |
-8.60 |
0.52 |
Oxidative or metabolic stress |
|
|
Chemokine (C-C motif) ligand 3 |
Ccl3 |
A08 |
-9.50 |
2.39 |
Inflammation |
|
|
|
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|
eGFP, enhanced green fluorescent protein; SD, standard deviation. |
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|
Wishart et al. Genome Biology 2008 9:R101 doi:10.1186/gb-2008-9-6-r101 |
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