Assignment of isochores for all completely sequenced vertebrate genomes using a consensus

Thorsten Schmidt¹ and Dmitrij Frishman¹^,2

¹Department of Genome-Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, D-85350 Freising, Germany

²Institute for Bioinformatics and Systems Biology (MIPS), Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße, D-85764 Neuherberg, Germany

author email corresponding author email

Genome Biology 2008, 9:R104doi:10.1186/gb-2008-9-6-r104


Published:	30 June 2008

Subject areas: Bioinformatics, Genome studies, Methods

Additional files

Additional data file 1:

Most borders are shifted between 10 and 100 kb among all methods. No borders are shifted more than 1 Mb in comparison to the BASIO borders. One exception is the least-squares segmentation, which has identical borders with the BASIO map in about 25% of all cases.

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Additional data file 2:

For all isochore assignments, more genes reside completely within a single stretch than one would expect by chance. All results are statistically significant (Chi-Square test, all p-values < 0.001).

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Additional data file 3:

Analysis of isochore families in all genomes and analysis of differences between methods

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