Comparison of isochore assignments in the human genome made by the different methods. All isochore maps show remarkable differences with respect to the number and the average length of their isochore segments. The IsoFinder and BASIO methods result in the most fine-grained segmentations while GC-Profile and least-squares produce less fragmented partitioning of the genome. The consensus map provides a compromise solution. (a) Number of isochore stretches. (b) Average isochore length.
Schmidt and Frishman Genome Biology 2008 9:R104 doi:10.1186/gb-2008-9-6-r104