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A selection of identified relevant clusters in the set of differentially expressed genes between metastatic and localized prostate cancer |
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| Cluster |
Number of genes |
Descriptive concepts |
|
|
||
| Up-regulated |
||
| A |
24 |
Kinetochores; mitosis; anaphase-promoting complex |
| B |
5 |
Nuclear proteins; tumor markers, biological |
| C |
3 |
Unfolded protein response |
| Down-regulated |
||
| A |
7 |
Complement system proteins |
| B |
7 |
Calponin; smooth muscle myosins |
| C |
4 |
Myosin phosphatase; smooth muscle (tissue) |
| D |
7 |
Extracellular matrix proteins |
| E |
5 |
Transcription factor; proto-oncogene proteins c-fos |
| F |
4 |
Cyclin-dependent kinases |
| G |
3 |
Melanosomes; membrane protein traffic; exocytosis |
| H |
5 |
Membrane transport proteins; symporter |
|
The most descriptive concepts are shown as given by the Anni annotation view. The two left-most columns depict how many genes in the cluster were either up- or down-regulated in metastasized prostate cancer. | ||
Jelier et al. Genome Biology 2008 9:R96 doi:10.1186/gb-2008-9-6-r96 |
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