Table 3

Summary of neo-Y specific mutations occurred in the cDNA of investigated genes

Gene symbol

Positions on neo-Y^a

Shared mutation

Polymorphic mutation

MYO1D

17a

One synonymous substitution

RPL19

17a

One synonymous substitution

One synonymous substitution

CACNB1

17a

A to S^b

CLTC

17a

Two synonymous substitutions

ZNF24

17a

One synonymous substitution

AKAP7

3b

Three synonymous substitutions; V to M

SYNE1

3b

One synonymous substitution; I to V; V to E^b

Two synonymous substitutions

SNX22

8

46 bp deletion in 3'-UTR

RIC8B

1a

S to P^b

SCN1A

3a

D to G^b

MPPE1

4a

One synonymous substitution

^aPositions correspond to chromosomal regions depicted in Figure 1a. ^bMissense mutations with drastic change of biochemical property of amino acid (polarity or charge), and those in bold represent sites that are highly conserved in other eutherian mammals with published sequences. We defined 'shared mutations' as those mutations detected in neo-Y alleles in both male black muntjacs, whereas 'polymorphic mutation' are those detected in only one male black muntjac.

Zhou et al. Genome Biology 2008 9:R98   doi:10.1186/gb-2008-9-6-r98