Engineering a DNA damage response without DNA damage
1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University Avenue, Toronto, ON, M5G 1X5 Canada
2 Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8 Canada
Genome Biology 2008, 9:227 doi:10.1186/gb-2008-9-7-227Published: 28 July 2008
Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.