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Engineering a DNA damage response without DNA damage

ManTek Yeung12 and Daniel Durocher12*

Author affiliations

1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University Avenue, Toronto, ON, M5G 1X5 Canada

2 Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8 Canada

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Citation and License

Genome Biology 2008, 9:227  doi:10.1186/gb-2008-9-7-227

Published: 28 July 2008

Abstract

Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.